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Sildenafil acts by inhibiting cGMP-specific phosphodiesterase type 5 (phosphodiesterase 5, PDE 5 ), an enzyme that promotes degradation of cGMP, which regulates blood flow in the penis.Professional athletes have been documented using sildenafil, believing the opening of their blood vessels will enrich their muscles.

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Common side effects include headaches and heartburn, as well as flushed skin.Sildenafil is broken down in the liver by hepatic metabolism using cytochrome p450 enzymes, mainly CYP450 3A4(major route), but also by CYP2C9 (minor route) hepatic isoenzymes.

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Concomitant use of soluble guanylyl cyclase stimulators, such as riociguat.

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Sildenafil is excreted as metabolites predominantly in the feces (about 80% of administered oral dose) and to a lesser extent in the urine (around 13% of the administered oral dose).

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Sildenafil should not be used if sexual activity is inadvisable due to underlying cardiovascular risk factors (such as recent heart surgery, stroke or heart attack, etc.).

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The major product of metabolisation by these enzymes is N-desmethylated sildenafil, which is metabolised further.

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See also: Drugs for erectile dysfunction and premature ejaculation.Nitric oxide (NO) in the corpus cavernosum of the penis binds to guanylate cyclase receptors, which results in increased levels of cGMP, leading to smooth muscle relaxation ( vasodilation ) of the intimal cushions of the helicine arteries.This metabolite also has an affinity for the PDE receptors, about 40% of that of sildenafil.Infertility — Not just a female condition; Cushing syndrome; Diabetic neuropathy.

Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.Rare but serious side effects include prolonged erections, which can lead to damage to the penis, and sudden-onset hearing loss.

Female Viagra is an oral drug used in order to improve sexual. will not go amiss.Viagra To Go Generic plays a vital role in inspiring consumers to reach for your products.

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This monograph has been modified to include the generic and brand name in many.Did viagra go generic Take this did viagra go generic medication abuse may result if a certain inherited.Care should be exercised by people who are also taking protease inhibitors for the treatment of HIV infection.In the United States, Pfizer received two patents for sildenafil: one for its indication to treat cardiovascular disease (marketed as Revatio) and another for its indication to treat erectile dysfunction (marketed as Viagra).

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